Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights
نویسندگان
چکیده
منابع مشابه
MINIREVIEW Properties and Functions of GAF Domains in Cyclic Nucleotide Phosphodiesterases and Other Proteins
This review focuses primarily on our current understanding of the structure and function of GAF domains in cyclic nucleotide phosphodiesterases (PDEs). The GAF domain was originally identified by Aravind and Ponting (1997) using the position-specific iterative BLAST method (Altschul et al., 1997). The consensus sequence defining GAF domains is taken from a characteristic primary sequence of che...
متن کاملProperties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins.
This review focuses primarily on our current understanding of the structure and function of GAF domains in cyclic nucleotide phosphodiesterases (PDEs). The GAF domain was originally identified by Aravind and Ponting (1997) using the position-specific iterative BLAST method (Altschul et al., 1997). The consensus sequence defining GAF domains is taken from a characteristic primary sequence of che...
متن کاملStructural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels.
Cyclic nucleotide-binding domains (CNBDs) that are present in various channel proteins play crucial roles in signal amplification cascades. Although atomic resolution structures of some of those CNBDs are available, the detailed mechanism by which they confer cyclic nucleotide-binding to the ion channel pore remains poorly understood. In this review, we describe structural insights about cyclic...
متن کاملCyclic Nucleotide Phosphodiesterases from Rat Anterior Pituitary
Phosphodiesterase activities for adenosine and guanosine 3’ : 5’-monophosphates (cyclic AMP and cyclic GMP) were demonstrated in particulate and soluble fractions of rat anterior pituitary gland. Both fractions contained higher activity for cyclic GMP hydrolysis than that for cyclic AMP hydrolysis when these activities were assayed at subsaturating substrate concentrations. Addition of protein ...
متن کاملCyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2
GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases. CyaB2, an adenylyl cyclase from Anabaena, contains two GAF domains in tandem at the N-terminus and an adenylyl cyclase domain at the C-terminus. Cyclic AMP, but not cGMP, binding to the GAF domains ...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2009.07.019